The new research study led by Standford Medicine published on JAMA Network1 suggests that a certain “cognitive biotype” of depression may respond poorly to standard antidepressants. 

Hold on: What’s a biotype? According to the American Psychological Association, a biotype refers to a group of individuals with a similar genetic makeup. In this case, biotype refers to people who share similar neuronal patterns when it comes to learning and processing information and regulating mood.

The research focused on those with a cognitive biotype that made them have more difficulty with planning ahead, holding concentration, and exercising self-control (as shown by brain imaging scans that measure activity in certain brain regions). The typical symptoms of depression, including trouble with executive functioning, decision-making, memory, concentration, and the ability to suppress negative emotions in favor of positive behavior, are all more pronounced in this cognitive biotype.

In the study, researchers took 1,008 adults with previously unmedicated major depressive disorder and randomly assigned each person one of three common antidepressants: escitalopram (also known as Lexapro), sertraline (Zoloft), and venlafaxine-XR (Effexor). A total of 712 participants completed the 8-week prescription.

Both before and after the antidepressant treatment, the participants’ depressive symptoms were measured using two surveys (one administered by a clinician and the other self-reported) and a cognitive assessment. 

In this assessment, participants completed a series of cognitive tasks to measure things like memory, decision speed, and attention span while an fMRI tracked their neuronal activity. 

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Harmony Evans is an award-winning author of Harlequin Kimani Romance, African-American romance, and so on. Harmony Evans is an award-winning author for Harlequin Kimani Romance, the leading publisher of African-American romance. Her 2nd novel, STEALING KISSES, will be released in November 2013. Harmony is a single mom to a beautiful, too-smart-for-her-own-good daughter, who makes her grateful for life daily. Her hobbies include cooking, baking, knitting, reading, and of course, napping and also review some of the best-selling and popular brands and services in the market and also write comprehensive blogs.


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